Alex W Hewitt Selected Research

trabecular meshwork-induced glucocorticoid response protein

1/2020	Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.
1/2019	Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies.
1/2017	Myocilin Predictive Genetic Testing for Primary Open-Angle Glaucoma Leads to Early Identification of At-Risk Individuals.
1/2017	Whole exome sequencing implicates eye development, the unfolded protein response and plasma membrane homeostasis in primary open-angle glaucoma.
8/2015	Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma.
6/2013	Higher prevalence of myocilin mutations in advanced glaucoma in comparison with less advanced disease in an Australasian disease registry.
2/2008	Myocilin allele-specific glaucoma phenotype database.
3/2007	Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds.
1/2007	Screening for glaucomatous disc changes prior to diagnosis of glaucoma in myocilin pedigrees.
1/2007	Myocilin Gly252Arg mutation and glaucoma of intermediate severity in Caucasian individuals.

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Alex W Hewitt Research Topics

Disease

29	Glaucoma 01/2021 - 02/2006
15	Open-Angle Glaucoma (Glaucoma, Open Angle) 09/2021 - 01/2007
8	Macular Degeneration (Age-Related Maculopathy) 01/2021 - 08/2006
6	Myopia 01/2022 - 07/2012
6	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 10/2009
6	Cataract (Cataracts) 01/2020 - 01/2015
6	Refractive Errors (Refractive Error) 05/2019 - 11/2008
6	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2019 - 09/2009
5	Keratoconus 01/2022 - 10/2011
4	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2018
4	Ganglion Cysts (Ganglion) 01/2021 - 01/2019
4	Obesity 07/2019 - 01/2018
3	Eye Diseases (Eye Disease) 07/2022 - 01/2014
3	Type 2 Diabetes Mellitus (MODY) 02/2022 - 09/2009
3	Hypertension (High Blood Pressure) 01/2021 - 01/2013
3	Inflammation (Inflammations) 08/2020 - 10/2015
3	Retinal Diseases 01/2020 - 07/2013
3	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2017 - 01/2016
3	Exfoliation Syndrome 01/2016 - 03/2008
3	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 03/2013 - 01/2011
2	Inborn Genetic Diseases (Disease, Hereditary) 07/2022 - 01/2017
2	Macular Edema 04/2022 - 02/2022
2	Astigmatism 01/2022 - 01/2013
2	Retinal Neovascularization 01/2022 - 01/2021
2	Esotropia (Esophoria) 01/2020 - 01/2018
2	Nevus (Nevi) 01/2019 - 11/2018
2	Melanoma (Melanoma, Malignant) 01/2019 - 11/2018
2	Optic Nerve Diseases (Optic Neuropathy) 10/2016 - 05/2014
2	Diabetes Mellitus 08/2016 - 09/2015
2	Fuchs' Endothelial Dystrophy 06/2012 - 02/2012
1	Heart Diseases (Heart Disease) 12/2021
1	Retinal Vein Occlusion 01/2021
1	Ischemia 01/2021
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Genetic Risk Score 01/2020
1	Amblyopia (Lazy Eye) 01/2020
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/2020
1	Exotropia (Exophoria) 01/2020
1	Anisometropia 01/2020
1	Retinal Detachment (Retinal Detachments) 01/2020
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019
1	Air Embolism (Gas Embolism) 12/2018
1	Optic Nerve Injuries 01/2018
1	Disease Susceptibility (Diathesis) 01/2018

Drug/Important Bio-Agent (IBA)

15	Retinaldehyde (Retinal)IBA 01/2021 - 10/2009
14	Proteins (Proteins, Gene)FDA Link 07/2019 - 09/2007
12	trabecular meshwork-induced glucocorticoid response proteinIBA 01/2020 - 02/2006
10	Biomarkers (Surrogate Marker)IBA 04/2022 - 07/2012
7	Biological ProductsIBA 12/2021 - 10/2010
5	Pharmaceutical PreparationsIBA 07/2022 - 05/2014
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2022 - 09/2009
4	DNA (Deoxyribonucleic Acid)IBA 09/2015 - 07/2013
3	Insulin (Novolin)FDA Link 02/2022 - 09/2015
3	CollagenIBA 01/2022 - 01/2018
3	MicroRNAs (MicroRNA)IBA 01/2022 - 06/2015
3	LipidsIBA 12/2021 - 08/2020
3	Complement Factor H (Factor H)IBA 01/2019 - 05/2008
3	Mitochondrial DNA (mtDNA)IBA 01/2018 - 01/2016
2	ApolipoproteinsIBA 01/2022 - 01/2013
2	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2013
2	hydroxide ionIBA 12/2017 - 06/2014
2	Vitamin D FDA LinkGeneric 12/2017 - 06/2014
2	P-2 (P 2)IBA 01/2012 - 09/2009
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 10/2011 - 01/2011
1	RNA (Ribonucleic Acid)IBA 07/2022
1	LDL CholesterolIBA 12/2021
1	Indicators and Reagents (Reagents)IBA 09/2021
1	Antihypertensive Agents (Antihypertensives)IBA 01/2021
1	Oxygen (Dioxygen)IBA 01/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021
1	Thymidine Monophosphate (TMP)IBA 01/2021
1	Endothelial Growth FactorsIBA 01/2021
1	Complement System Proteins (Complement)IBA 08/2020
1	C-Reactive ProteinIBA 02/2020
1	Illicit Drugs (Recreational Drugs)IBA 01/2020
1	Cholinergic Agents (Cholinergics)IBA 01/2020
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020
1	GlucocorticoidsIBA 01/2020
1	NucleotidesIBA 01/2020
1	Apolipoprotein E4IBA 10/2019
1	Blood Glucose (Blood Sugar)IBA 10/2019
1	Contraceptive Agents (Contraceptives)IBA 05/2019
1	SteroidsIBA 05/2019
1	telomerase RNA (bTR)IBA 11/2018
1	UteroglobinIBA 02/2018
1	Presenilin-2IBA 01/2018
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2018
1	Presenilin-1IBA 01/2018
1	Tryptophan (L-Tryptophan)FDA Link 01/2018
1	Testosterone (Sustanon)FDA Link 01/2018

Therapy/Procedure

8	Therapeutics 07/2022 - 01/2012
2	Injections 04/2022 - 01/2021
2	Intravitreal Injections 01/2022 - 01/2021
2	Contact Lenses 01/2022 - 01/2021
1	Eyeglasses (Spectacles) 01/2021
1	Phacoemulsification 01/2020
1	Ligation 01/2019
1	Intravenous Injections 12/2018